[Immediate changes in intraocular pressure after an intravitreal injection of 2.5 mg of bevacizumab].

PURPOSE To report the immediate changes of intraocular (IOP) pressure after an intravitreal injection of 2.5mg (0.1 ml) of bevacizumab. METHODS Prospective, non-controlled, interventional case series of 45 patients undergoing intravitreal injection of 2.5mg (0.1 mL) of bevacizumab for a variety of retinal disorders. IOP was measured with a Goldmann tonometer at baseline, immediately after, 30 minutes and one day after injection in all of the cases. The main outcome measured was the IOP immediately after injection. RESULTS At baseline the mean IOP was 16.6±2.8mm Hg (range, 10-24 mm Hg; median, 16 mm Hg; 25(th) percentile, 14 mm Hg and 75(th) percentile, 18 mm Hg). IOP rose to 53.9±18.2mm Hg (range, 16-78 mm Hg, median, 54 mm Hg; 25(th) percentile, 40 mm Hg and 75(th) percentile, 70 mm Hg; p<0.001) immediately after the injection. After 30 minutes, the IOP normalized but was still higher than baseline with a mean of 19.8±5.2 mm Hg (range, 10-36 mm Hg; median,18 mm Hg; 25(th) percentile,16 mm Hg and 75(th) percentile, 24 mm Hg; P<.01). At 24 hours the IOP was 15.7±3.1 mm Hg (range,10-24 mm Hg; median, 16 mm Hg; 25(th) percentile,14 mm Hg and 75(th) percentile,18 mm Hg; p>0.05). CONCLUSIONS An intravitreal injection of 2.5mg (0.1 ml) of bevacizumab causes a transient elevation of IOP that tends to return to normal 30 minutes later.